The role of tissue-resident macrophages in the development and treatment of inflammatory bowel disease

S Ma, J Zhang, H Liu, S Li, Q Wang - Frontiers in cell and …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a
refractory disease with many immune abnormalities and pathologies in the gastrointestinal …

emerging drug therapies in inflammatory bowel disease

LB Grossberg, K Papamichael… - Alimentary …, 2022 - Wiley Online Library
Background The landscape of inflammatory bowel disease (IBD) treatment is rapidly
expanding with the development of new therapeutic options. Aim To review the mechanisms …

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

N Itokawa, M Oshima, S Koide, N Takayama… - Nature …, 2022 - nature.com
Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here,
we present an integrated analysis of transcriptome and chromatin accessibility of aged …

Therapeutic effect of baicalin on inflammatory bowel disease: A review

X Wang, L Xie, J Long, K Liu, J Lu, Y Liang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Baicalin (BI) is an important biologically active flavonoid
isolated from the root of Scutellaria radix (Huang Qin). Traditionally Scutellaria radix was the …

Wielding the double-edged sword: Redox drug delivery systems for inflammatory bowel disease

Y Chen, M Shui, Q Yuan, CT Vong, Z Yang… - Journal of Controlled …, 2023 - Elsevier
The etiology of inflammatory bowel disease (IBD) is extremely complex and related to an
excessive immune response that results in the pathologically release of reactive oxygen …

Health benefits of dietary fiber for the management of inflammatory bowel disease

K Yusuf, S Saha, S Umar - Biomedicines, 2022 - mdpi.com
Crohn's disease (CD) and ulcerative colitis (UC), two components of inflammatory bowel
disease (IBD), are painful conditions that affect children and adults. Despite substantial …

Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways

MN Aydemir, HB Aydemir, EM Korkmaz, M Budak… - Gene Reports, 2021 - Elsevier
Recently an outbreak that emerged in Wuhan, China in December 2019, spread to the
whole world in a short time and killed> 1,410,000 people. It was determined that a new type …

JAK inhibitors: A new dawn for oral therapies in inflammatory bowel diseases

C Herrera-deGuise, X Serra-Ruiz, E Lastiri… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition of the
gastrointestinal tract that requires chronic treatment and strict surveillance. Development of …

Astragaloside IV alleviates the experimental DSS-induced colitis by remodeling macrophage polarization through STAT signaling

L Tian, JL Zhao, JQ Kang, S Guo, N Zhang… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal
inflammation, which currently lacks safe and effective medicine. Some previous studies …

Chinese medicine in the treatment of ulcerative colitis: the mechanisms of signaling pathway regulations

S Zheng, T Xue, B Wang, H Guo… - The American Journal of …, 2022 - World Scientific
Ulcerative colitis (UC) is a common clinical inflammatory bowel disease characterized by
repeated attacks, difficult treatment, and great harm to the physical and mental health of the …