[HTML][HTML] Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment

V Lelarge, R Capelle, F Oger, T Mathieu, B Le Calvé - npj Aging, 2024 - nature.com
The involvement of cellular senescence in the initiation and propagation of diseases is
clearly characterized, making the elimination of senescent cells essential to treat age-related …

Overview of tumor immunotherapy based on approved drugs

Z Chen, T Hu, J Zhou, X Gu, S Chen, Q Qi, L Wang - Life Sciences, 2024 - Elsevier
Tumor immunotherapy has become a new hotspot for cancer treatment. Various
immunotherapies, such as immune checkpoint inhibitors, oncolytic viruses (OVs), cytokines …

CAR-T cell therapy: Where are we now, and where are we heading?

JY Wang, L Wang - Blood Science, 2023 - mednexus.org
Chimeric antigen receptor (CAR)-T-cell therapies have exhibited remarkable efficacy in the
treatment of hematologic malignancies, with 9 CAR-T-cell products currently available …

Research advances of nanoparticles for CAR-T therapy in solid tumors

B Chen, L Gong, J Feng, M Jin, L Chen, Z Gao… - Chinese Chemical …, 2023 - Elsevier
As one of the most promising adoptive T-cell therapies, chimeric antigen receptor T-cell
(CAR-T) therapy has acquired Food and Drug Administration (FDA) approval for a variety of …

Finding your CAR: The road ahead for engineered T-cells

PH Chen, R Raghunandan, JS Morrow… - The American Journal of …, 2024 - Elsevier
Adoptive cellular therapy using chimeric antigen receptors (CAR) has transformed
immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field …

Chimeric antigen receptors:“CARs” in the fast lane for rheumatology

NM Johnson, F Koumpouras - Current Opinion in Rheumatology, 2024 - journals.lww.com
Chimeric antigen receptors: “CARs” in the fast lane for rheu... : Current Opinion in
Rheumatology Chimeric antigen receptors: “CARs” in the fast lane for rheumatology …

[HTML][HTML] Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery

T Katopodi, S Petanidis, D Anestakis, C Charalampidis… - Pharmaceutics, 2023 - mdpi.com
Following its therapeutic effect in hematological metastasis, chimeric antigen receptor (CAR)
T cell therapy has gained a great deal of attention during the last years. However, the …

PTPRZ1-targeting RNA CAR-T cells exert antigen-specific and bystander antitumor activity in glioblastoma

D Martinez Bedoya, E Marinari, S Davanture… - bioRxiv, 2023 - biorxiv.org
The great success of chimeric antigen receptor (CAR)-T cell therapy in B-cell malignancies
has prompted its translation to solid tumors. In the case of glioblastoma (GBM), clinical trials …

[HTML][HTML] CAR T-Cell Therapy: A New Era in Cancer Immunotherapy

M Sahlolbei, A Ahmadieh-Yazdi, M Rostamipoor… - 2024 - intechopen.com
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary development in the field of
cancer immunotherapy, offering a targeted approach to combat various hematologic …

Using CRISPR-Cas9 gene editing to engineer the next generation of CAR T cells

S Sabolová - 2024 - dspace.cuni.cz
Chimeric antigen receptor (CAR T) cell therapy is currently a successful treatment for
hematological malignancies and is also a rapidly evolving field of research for treating solid …