The role of transforming growth factor-β (TGF-β) during tumorigenesis is complex and
paradoxical, reflecting its ability to function as a tumor suppressor in normal and early-stage …

Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …

Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …

The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or
tumor promotional, depending on context. The metastatic regulator, Six1, was recently …

Recent fate-mapping studies concluded that EMT is not required for metastasis of
carcinomas. Here we challenge this conclusion by showing that these studies failed to …

The epithelial to mesenchymal transition (EMT) represents a crucial event during cancer
progression and dissemination. EMT is the conversion of carcinoma cells from an epithelial …

Abstract The Eyes Absent (EYA) family of proteins is an atypical group of four dual-
functioning protein phosphatases (PP), which have been linked to many vital cellular …

Phosphatases of the haloacid dehalogenase (HAD) superfamily of hydrolases are an
ancient and very large class of enzymes that have evolved to dephosphorylate a wide range …

SIX1 interacts with EYA to form a bipartite transcription factor essential for mammalian
development. Loss of function of this complex causes branchio-oto-renal (BOR) syndrome …

The epithelial-to-mesenchymal transition (EMT) is a critical developmental process that has
recently come to the forefront of cancer biology. In breast carcinomas, acquisition of a …