Eyes absent homolog 2 (EYA2), a transcriptional activator, is pivotal for organ development,
but aberrant regulation of EYA2 has been reported in multiple human tumors. However, the …

Tumor environment plays a pivotal role in determining cancer biology characteristics.
Cytokine factors, as a critical component in tumor milieu, execute distinct functions in the …

Abstract The Eyes Absent family (EYA1-4) are a group of dual function proteins that act as
both tyrosine phosphatases and transcriptional co-activators. EYA proteins play a vital role …

Sine Oculis Homeobox Homolog 1 (SIX1) is reported to promote cancer initiation and
progression in many preclinical models and is demonstrated in human cancer tissues …

Sine oculis homeobox homolog 1 (Six1) is a developmentally important transcription factor
that regulates cellular proliferation, apoptosis, and dissemination during embryogenesis …

The overexpression of eyes absent (Eya) 2 has been found in several human cancers.
However, its biological roles and clinical significance in human astrocytoma have not yet …

Herein, we used DIANA TOOLS, gene expression profiling interactive analysis and other
bioinformatics databases to predict regulatory pathways in breast cancer. Accordingly, we …

Blood vessels are one of the major routes for the dissemination of cancer cells. Malignant
tumors release growth factors such as vascular endothelial growth factor (VEGF) to induce …

Human eyes absent (EYA) proteins possess Tyr phosphatase activity, which is critical for
numerous cancer and metastasis promoting activities, making it an attractive target for …

The retinal determinant gene network (RDGN), originally discovered as a critical
determinator in Drosophila eye specification, has become an important regulatory network in …