Developmental programming and transgenerational transmission of obesity

MH Vickers - Annals of Nutrition and Metabolism, 2014 - karger.com
The global obesity pandemic is often causally linked to marked changes in diet and lifestyle,
namely marked increases in dietary intakes of high-energy diets and concomitant reductions …

[HTML][HTML] Oxidative stress in mouse sperm impairs embryo development, fetal growth and alters adiposity and glucose regulation in female offspring

M Lane, NO McPherson, T Fullston, M Spillane… - PLoS …, 2014 - journals.plos.org
Paternal health cues are able to program the health of the next generation however the
mechanism for this transmission is unknown. Reactive oxygen species (ROS) are increased …

Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study

CA Robledo, E Yeung, P Mendola… - Environmental …, 2015 - ehp.niehs.nih.gov
Background: Persistent organic pollutants (POPs) are developmental toxicants, but the
impact of both maternal and paternal exposures on offspring birth size is largely unexplored …

Germ cell origins of posttraumatic stress disorder risk: the transgenerational impact of parental stress experience

AB Rodgers, TL Bale - Biological psychiatry, 2015 - Elsevier
Altered stress reactivity is a predominant feature of posttraumatic stress disorder (PTSD) and
may reflect disease vulnerability, increasing the probability that an individual will develop …

Epigenetics in fish gametes and early embryo

C Labbé, V Robles, MP Herraez - Aquaculture, 2017 - Elsevier
The spermatozoa and oocyte are very specialized cells which possess the unique ability to
fuse and to produce an embryo. This embryo will develop into a mature organism capable of …

The emerging role of microRNAs and nutrition in modulating health and disease

SA Ross, CD Davis - Annual review of nutrition, 2014 - annualreviews.org
Understanding the molecular mechanisms that inform how diet and dietary supplements
influence health and disease is an active research area. One such mechanism concerns the …

Father's environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study

C Svanes, J Koplin, SM Skulstad… - International journal …, 2017 - academic.oup.com
Background: Whereas it is generally accepted that maternal environment plays a key role in
child health, emerging evidence suggests that paternal environment before conception also …

Effects of obesity and diabetes on the epigenetic modification of mammalian gametes

XH Ou, CC Zhu, SC Sun - Journal of cellular physiology, 2019 - Wiley Online Library
Obesity and diabetes are closely associated with numerous reproductive disorders,
including termination of ovulation, irregular menstruation, low fertility, abortion, and risky …

The influence of seminal plasma on offspring development and health

HL Morgan, AJ Watkins - Seminars in cell & developmental biology, 2020 - Elsevier
The concept that a father's wellbeing at the time of conception influences the development
and long-term health of his offspring is now well established. However, the mechanisms …

Paternal high‐fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring

SF Ng, RCY Lin, CA Maloney, NA Youngson… - The FASEB …, 2014 - Wiley Online Library
We previously showed that paternal high‐fat diet (HFD) consumption programs β‐cell
dysfunction in female rat offspring, together with transcriptome alterations in islets. Here we …