Going Full TeRM: The Seminal Role of Tissue-Resident Macrophages in Organ Remodeling during Pregnancy and Lactation

Y Wu, YC Teh, SZ Chong - The Journal of Immunology, 2024 - journals.aai.org
During pregnancy and lactation, the uterus and mammary glands undergo remarkable
structural changes to perform their critical reproductive functions before reverting to their …

[HTML][HTML] Potential pathological mechanisms and pharmacological interventions for cadmium-induced miscarriage

Y Li, J Liu, N Ran, C Zheng, PP Wang, J Li… - Ecotoxicology and …, 2024 - Elsevier
The prevalence of cadmium (Cd) contamination has emerged as a significant global
concern. Exposure to Cd during pregnancy is associated with adverse pregnancy outcomes …

Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation

X Chen, QL Song, JY Wang, R Ji, ZH Li, ML Cao… - The American Journal of …, 2023 - Elsevier
Unexplained recurrent spontaneous abortion (URSA) has been associated with the
dysfunction of trophoblasts and decidual macrophages. Current evidence suggests that …

[HTML][HTML] Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA

C Wei, Y Wei, J Cheng, X Tan, Z Zhou, S Lin… - Frontiers in …, 2023 - frontiersin.org
Background Recurrent pregnancy loss defined as the occurrence of two or more pregnancy
losses before 20-24 weeks of gestation, is a prevalent and significant pathological condition …

FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K/AKT and NF-κB signaling pathways

X Chen, QL Song, JY Wang, R Ji, ML Cao… - Free Radical Biology …, 2023 - Elsevier
Abstract FK506-binding protein 5 (FKBP5) contributes to many diseases; However, it
remains unclear whether FKBP5 is relevant to recurrent spontaneous abortion (RSA) and …

Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns

S Lv, M Chen, Z Li, Z Huang, S Wan, S Kuang… - International …, 2024 - Elsevier
Fetal growth restriction (FGR) is a major cause of premature and low-weight births, which
increases the risk of necrotizing enterocolitis (NEC); however, the association remains …

Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

CCRA Gonçalves, BM Feitosa… - American Journal of …, 2023 - Wiley Online Library
Currently, obesity is considered a global public health problem. It is the main risk factor for
noncommunicable diseases and reproductive complications, such as recurrent miscarriage …

Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage

JX Sun, Y Yao, WX Li, X Su, H Yang, Z Lu, C Liu… - Epigenetics, 2024 - Taylor & Francis
Decidual macrophages are the second-largest immune cell group at the maternal-foetal
interface. They participate in apoptotic cell removal, and protect the foetus from …

Non-coding RNA regulates the immune microenvironment in recurrent spontaneous abortion (RSA): new insights into immune mechanisms

C Tang, W Hu - Biology of Reproduction, 2024 - academic.oup.com
Recurrent spontaneous abortion (RSA) has various causes, including chromosomal
abnormalities, prethrombotic state, and abnormal uterine anatomical factors. However, the …

The epidemiology of pregnancy loss: global burden, variable risk factors, and predictions

F Tong, Y Wang, Q Gao, Y Zhao, X Zhang… - Human …, 2024 - academic.oup.com
STUDY QUESTION Is the incidence of pregnancy loss correlated with various geographic,
socio-demographic, and age stratifications at the societal and national levels, and what are …