During natural tissue regeneration, tissue microenvironment and stem cell niche including
cell–cell interaction, soluble factors, and extracellular matrix (ECM) provide a train of …

Nanotopography presents an effective physical approach for biomaterial cell manipulation
mediated through material-extracellular matrix interactions. The extracellular matrix that …

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Stem cell therapies are limited by poor cell survival and engraftment. A hurdle to the use of
materials for cell delivery is the lack of understanding of material properties that govern …

Mesenchymal stem cells adopt differentiation pathways based upon cumulative effects of
mechanosensing. A cell's mechanical microenvironment changes substantially over the …

Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental
implants. Despite the majority of Ti implants having long-term success, premature failure due …

One of the major issues in tissue engineering is regulation of stem cell differentiation toward
specific lineages. Unlike biological and chemical signals, physical signals with adjustable …

Periosteum plays a pivotal role in vascularization, ossification and remodeling during the
healing process of bone injury. However, there are few studies focused on the construction …

Growth factors and mechanical cues synergistically affect cellular functions, triggering a
variety of signaling pathways. The molecular levels of such cooperative interactions are not …