Lipid rafts in exosome biogenesis

GO Skryabin, AV Komelkov, EE Savelyeva… - Biochemistry …, 2020 - Springer
Exosomes (secreted extracellular vesicles formed in the intracellular vesicular transport
system) play a crucial role in distant cell–cell communication. Exosomes transfer active …

Caveolin‐1, cancer and therapy resistance

J Ketteler, D Klein - International journal of cancer, 2018 - Wiley Online Library
Resistance of solid tumors to chemo‐and radiotherapy remains a major obstacle in anti‐
cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is …

A pilot clinical study on the prognostic relevance of plasmatic exosomes levels in oral squamous cell carcinoma patients

S Rodríguez Zorrilla, M Pérez-Sayans, S Fais… - Cancers, 2019 - mdpi.com
Background: To evaluate the relationship between the plasmatic CD63 and CAV1 positive
exosome levels, in patients with OSCC before and after surgical treatment and to correlate it …

Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment

XL Qian, YH Pan, QY Huang, YB Shi… - OncoTargets and …, 2019 - Taylor & Francis
Human breast cancer is one of the most frequent cancer diseases and causes of death
among female population worldwide. It appears at a high incidence and has a high …

[HTML][HTML] The Role of AMPK/mTOR Signaling Pathway in Anticancer Activity of Metformin: This paper is dedicated to the 70th anniversary of the founding of Physiologia …

N Chomanicova, A Gazova, A Adamickova… - Physiological …, 2021 - ncbi.nlm.nih.gov
Metformin (MTF) is a widely used drug for the treatment of diabetes mellitus type 2 (DM2)
and frequently used as an adjuvant therapy for polycystic ovarian syndrome, metabolic …

[HTML][HTML] Cell-in-cell phenomenon and its relationship with tumor microenvironment and tumor progression: A review

X Wang, Y Li, J Li, L Li, H Zhu, H Chen… - Frontiers in cell and …, 2019 - frontiersin.org
The term cell-in-cell, morphologically, refers to the presence of one cell within another. This
phenomenon can occur in tumors but also among non-tumor cells. The cell-in-cell …

[HTML][HTML] Identification and integration analysis of a novel prognostic signature associated with cuproptosis-related ferroptosis genes and relevant lncRNA regulatory …

T Wang, X Jiang, Y Lu, Y Ruan, J Wang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Lung adenocarcinoma (LUAD) is a highly prevalent malignancy worldwide, and its clinical
prognosis assessment and treatment is a major research direction. Both ferroptosis and …

LINC81507 act as a competing endogenous RNA of miR-199b-5p to facilitate NSCLC proliferation and metastasis via regulating the CAV1/STAT3 pathway

W Peng, D He, B Shan, J Wang, W Shi, W Zhao… - Cell death & …, 2019 - nature.com
Lung cancer is the leading cause of cancer-related mortality worldwide. Recently,
accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial …

Celastrol attenuates lipid accumulation and stemness of clear cell renal cell carcinoma via CAV-1/LOX-1 pathway

CJ Zhang, N Zhu, YX Wang, LP Liu, TJ Zhao… - Frontiers in …, 2021 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is characterized by abnormal lipid accumulation.
Celastrol is a pentacyclic triterpene extracted from Tripterygium wilfordii Hook F with anti …

Prognostic significance and therapeutic implications of Caveolin-1 in gastrointestinal tract malignancies

K Kamposioras, M Vassilakopoulou, A Anthoney… - Pharmacology & …, 2022 - Elsevier
Abstract Caveolin-1 (CAV1) is expressed in several solid tumors both in cancerous cells as
well as in tumor stroma and is reported to be related to cancer progression, metastasis …