Nutritional niches of cancer therapy-induced senescent cells

À Llop-Hernández, S Verdura, E Cuyàs, JA Menendez - Nutrients, 2022 - mdpi.com
Therapy-induced senescence (TIS) is a state of stable proliferative arrest of both normal and
neoplastic cells that is triggered by exposure to anticancer treatments. TIS cells acquire a …

Radiation-induced cellular senescence reduces susceptibility of glioblastoma cells to oncolytic vaccinia virus

QT Storozynsky, X Han, S Komant, KC Agopsowicz… - Cancers, 2023 - mdpi.com
Simple Summary Novel therapeutic approaches combining oncolytic virus (OV) therapy and
radiotherapy are being investigated to improve treatment for glioblastoma (GBM). However …

Cancer associated fibroblasts and senescent thyroid cells in the invasive front of thyroid carcinoma

E Minna, S Brich, K Todoerti, S Pilotti, P Collini… - Cancers, 2020 - mdpi.com
Thyroid carcinoma (TC) comprises several histotypes with different aggressiveness, from
well (papillary carcinoma, PTC) to less differentiated forms (poorly differentiated and …

Mechanisms of cancer stem cell senescence: Current understanding and future perspectives

DY Zhang, MJ Monteiro, JP Liu… - Clinical and Experimental …, 2021 - Wiley Online Library
Cancer stem cells (CSCs) are a small population of heterogeneous tumor cells with the
capacity of self‐renewal and aberrant differentiation for immortality and divergent lineages of …

[HTML][HTML] Matrix-driven changes in metabolism support cytoskeletal activity to promote cell migration

Y Wu, MR Zanotelli, J Zhang, CA Reinhart-King - Biophysical Journal, 2021 - cell.com
The microenvironment provides both active and passive mechanical cues that regulate cell
morphology, adhesion, migration, and metabolism. Although the cellular response to those …

Tactics of cancer invasion: solitary and collective invasion

T Nagai, T Ishikawa, Y Minami… - The journal of …, 2020 - academic.oup.com
Much attention has been paid on the mechanism of cancer invasion from the viewpoint of
the behaviour of individual cancer cells. On the other hand, histopathological analyses of …

Downregulation of HINFP induces senescence-associated secretory phenotype to promote metastasis in a non-cell-autonomous manner in bladder cancer

X Zheng, Z Liu, J Zhong, L Zhou, J Chen, L Zheng, Z Li… - Oncogene, 2022 - nature.com
Transcription dysregulation is a salient characteristic of bladder cancer (BC), but no
appropriate therapeutic target for it has been established. Here, we found that …

Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol

JY Kim, KH Cho, BY Jeong, CG Park… - Experimental & Molecular …, 2020 - nature.com
Rab coupling protein (RCP) is upregulated in head and neck squamous cell carcinoma
(HNSCC) and is correlated with the progression and survival of patients. However, the role …

ABCA1-Mediated EMT Promotes Papillary Thyroid Cancer Malignancy through the ERK/Fra-1/ZEB1 Pathway

JH Park, JK Myung, SJ Lee, H Kim, S Kim, SB Lee… - Cells, 2023 - mdpi.com
Papillary thyroid cancer (PTC) is the most prevalent histological type of thyroid cancer (TC)
worldwide. Although tumor metastasis occurs in regional lymph nodes, distant metastasis …

Cellular senescence: from anti-cancer weapon to anti-aging target

L Yuan, PB Alexander, XF Wang - Science China Life Sciences, 2020 - Springer
Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the
production and secretion of inflammatory molecules. Early studies described oncogene …