Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)
AC Tan - Thoracic cancer, 2020 - Wiley Online Library
The traditional classification of lung cancer into small cell lung cancer and non‐small cell
lung cancer (NSCLC) has been transformed with the increased understanding of the …
lung cancer (NSCLC) has been transformed with the increased understanding of the …
Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy
Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
The role of mTOR signaling as a therapeutic target in cancer
NV Popova, M Jücker - International Journal of Molecular Sciences, 2021 - mdpi.com
The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
FDA-approved and emerging next generation predictive biomarkers for immune checkpoint inhibitors in cancer patients
Y Wang, Z Tong, W Zhang, W Zhang, A Buzdin… - Frontiers in …, 2021 - frontiersin.org
A patient's response to immune checkpoint inhibitors (ICIs) is a complex quantitative trait,
and determined by multiple intrinsic and extrinsic factors. Three currently FDA-approved …
and determined by multiple intrinsic and extrinsic factors. Three currently FDA-approved …
A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance
Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …
Autophagy in malignant transformation and cancer progression
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …
such a homeostatic activity constitutes a robust barrier against malignant transformation …
PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
The protein kinases regulate cellular functions such as transcription, translation,
proliferation, growth and survival by the process of phosphorylation. Over activation of …
proliferation, growth and survival by the process of phosphorylation. Over activation of …
PTEN: multiple functions in human malignant tumors
M Milella, I Falcone, F Conciatori, U Cesta Incani… - Frontiers in …, 2015 - frontiersin.org
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
The role of hypoxia in glioblastoma invasion
AR Monteiro, R Hill, GJ Pilkington, PA Madureira - Cells, 2017 - mdpi.com
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …