Regular physical activity positively influences whole body energy metabolism and substrate
handling in exercising muscle. While it is recognized that the effects of exercise extend …

RAP1 is part of shelterin, the protective complex at telomeres. RAP1 also binds along
chromosome arms, where it is proposed to regulate gene expression. To investigate the …

Ginsenoside Rb1 (Rb1), a natural compound extracted from ginseng, exerts anti-obesity
activity and improves insulin sensitivity in high-fat diet (HFD)-induced obese rats. The …

Autophagy is an intracellular degradation pathway for large protein aggregates and
damaged organelles. Recent studies have indicated that autophagy targets cargoes through …

Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic
fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of …

Mitochondrial β-oxidation is the most prominent pathway for fatty acid oxidation but
alternative oxidative metabolism exists. Fatty acid ω-oxidation is one of these pathways and …

Thiazolidinediones are a class of Peroxisome Proliferator Activated Receptor γ (PPARγ)
agonists that reduce insulin resistance in type 2 diabetic patients. Although no detectable …

Hepatitis C virus (HCV) is a leading cause of chronic liver disease. The identification and
characterization of key host cellular factors that play a role in the HCV replication cycle are …

Sterol regulatory element binding proteins (SREBPs) regulate the expression of a number of
enzymes, which catalyze the synthesis of fatty acids, cholesterol, triglycerides, and …

Background & Aims PARP1 is a key mediator of cellular stress responses and critical in
multiple physiological and pathophysiological processes of cells. However, whether it is …