Background The prognosis of people with metastatic cutaneous melanoma, a skin cancer, is
generally poor. Recently, new classes of drugs (eg immune checkpoint inhibitors and small …

Since dacarbazine was approved for treating metastatic melanoma in the 1970s, numerous
studies have evaluated whether different schedules and dacarbazine-based combinations …

We undertook a systematic review of 41 randomised studies in disseminated melanoma,
identified by a comprehensive search. We aimed to investigate rates of response to various …

Summation Cancer immunotherapy consists of approaches that modify the host immune
system, and/or the utilization of components of the immune system, as cancer treatment …

BACKGROUND: Advanced melanomas (non-resectable Stage-III/IV) are fatal, with few
effective treatments. It remains unclear if other drugs offer improvements over the standard …

Background Malignant melanoma, one of the most aggressive of all skin cancers, is
increasing in incidence throughout the world. Surgery remains the cornerstone of curative …

Background: The addition of cytokines to chemotherapy (CT) has obtained encouraging but
contradictory results in metastatic melanoma. In this phase III trial, we compared the effects …

Melanoma is the most aggressive form of skin cancer and advantages stages are inevitably
resistant to conventional therapeutic agents. In particular, the inability of undergo apoptosis …

In several phase II-trials encouraging tumour responses rates in advanced metastatic
melanoma (stage IV; AJCC-classification) have been reported for the application of …

Melanoma is the most aggressive form of skin cancer and advanced stages are inevitably
resistant to conventional therapeutic agents. In particular, the inability of undergo apoptosis …