Accurate intraoperative tumour margin assessment is a major challenge in neurooncology,
where sparse tumours beyond the bulk tumour are left undetected under conventional …

Introduction We aimed to evaluate the changing patterns in the management of glioblastoma
(GBM) and impact on survival outcomes over a 20‐year period. Methods This is a …

Medical laser applications based on widespread research and development is a very
dynamic and increasingly popular field from an ecological as well as an economic point of …

Background and Objectives Fluorescence image‐guided surgery (FIGS), with contrast
provided by 5‐ALA‐induced PpIX, has been shown to enable a higher extent of resection of …

There would be clinical value in a miniature optical-sectioning microscope to enable in vivo
interrogation of tissues as a real-time and noninvasive alternative to gold-standard …

Molecular imaging is the next frontier in image-guided therapy promising to increase
surgical precision. In vivo molecular imaging modalities, such as positron emission …

Video-rate optical-sectioning microscopy of living organisms would allow for the
investigation of dynamic biological processes and would also reduce motion artifacts …

Background Although optical spectroscopy promises improved lateral resolution for cancer
imaging, its clinical use is seriously impeded by background fluorescence and photon …

Surgical guidance with fluorescence has been demonstrated in individual clinical trials for
decades, but the scientific and commercial conditions exist today for a dramatic increase in …

Simple Summary This review delves into novel techniques in brain malignancy
management. Fast biopsy techniques offer a rapid and minimally invasive diagnosis, while …