N6-methyladenosine-mediated gene regulation and therapeutic implications
Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …
modification in eukaryotes and is at the front line of biological and biomedical research. This …
Small RNA modifications: regulatory molecules and potential applications
Q Xiong, Y Zhang - Journal of Hematology & Oncology, 2023 - Springer
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …
METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner
R Zhang, Y Qu, Z Ji, C Hao, Y Su, Y Yao, W Zuo… - Cellular & molecular …, 2022 - Springer
Background METTL3 is the core catalytic enzyme in m6A and is involved in a variety of
cardiovascular diseases. However, whether and how METTL3 plays a role during …
cardiovascular diseases. However, whether and how METTL3 plays a role during …
RNA modifications in cardiovascular health and disease
RNA is not always a faithful copy of DNA. Advances in tools enabling the interrogation of the
exact RNA sequence have permitted revision of how genetic information is transferred. We …
exact RNA sequence have permitted revision of how genetic information is transferred. We …
Mechanism of METTL3-Mediated m6A Modification in Cardiomyocyte Pyroptosis and Myocardial Ischemia–Reperfusion Injury
X Wang, Y Li, J Li, S Li, F Wang - Cardiovascular drugs and therapy, 2023 - Springer
Objective Myocardial ischemia/reperfusion (MI/R) injury is a complicated pathophysiological
process associated with cardiomyocyte pyroptosis. Methyltransferase-like protein 3 …
process associated with cardiomyocyte pyroptosis. Methyltransferase-like protein 3 …
N6-methyladenosine RNA methylation in cardiovascular diseases
C Liu, L Gu, W Deng, Q Meng, N Li, G Dai… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) modification is the most universal and abundant post-
transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR …
transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR …
RNA modification in cardiovascular disease: implications for therapeutic interventions
C Wang, X Hou, Q Guan, H Zhou, L Zhou… - … and Targeted Therapy, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …
N6 -Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review
S Wu, XF Li, YY Wu, SQ Yin, C Huang, J Li - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA), one of the most common autoimmune diseases, is characterized
by immune cell infiltration, fibroblast-like synovial cell hyperproliferation, and cartilage and …
by immune cell infiltration, fibroblast-like synovial cell hyperproliferation, and cartilage and …
Programmed release METTL3-14 inhibitor microneedle protects myocardial function by reducing Drp1 m6A modification-mediated mitochondrial fission
B Huang, L Xie, M Ke, Y Fan, J Tan… - ACS Applied Materials …, 2023 - ACS Publications
M6A modification is an RNA-important processing event mediated by methyltransferases
METTL3 and METTL14 and the demethylases. M6A dynamic changes after myocardial …
METTL3 and METTL14 and the demethylases. M6A dynamic changes after myocardial …
N6-methyladenosine (m6A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner
H Shen, K Xie, M Li, Q Yang, X Wang - Cell death discovery, 2022 - nature.com
Recent studies have identified that N6-methyladenosine (m6A) extensively participates in
the myocardial injury pathophysiological process. However, the role of m6A on sepsis …
the myocardial injury pathophysiological process. However, the role of m6A on sepsis …