[PDF][PDF] Novel approaches for vaccine development

MS Gebre, LA Brito, LH Tostanoski, DK Edwards… - Cell, 2021 - cell.com
Vaccines are critical tools for maintaining global health. Traditional vaccine technologies
have been used across a wide range of bacterial and viral pathogens, yet there are a …

[HTML][HTML] Delivery of STING agonists for adjuvanting subunit vaccines

S Van Herck, B Feng, L Tang - Advanced drug delivery reviews, 2021 - Elsevier
Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen
recognition receptors have been developed as potent adjuvants to optimize the …

[HTML][HTML] Development of vaccine formulations: past, present, and future

C D'Amico, F Fontana, R Cheng, HA Santos - Drug Delivery and …, 2021 - Springer
The current situation, heavily influenced by the ongoing pandemic, puts vaccines back into
the spotlight. However, the conventional and traditional vaccines present disadvantages …

[HTML][HTML] Gold nanoparticle-based platforms for vaccine development

RM Ferrando, L Lay, L Polito - Drug Discovery Today: Technologies, 2020 - Elsevier
Since their discovery, therapeutic or prophylactic vaccines represent a promising option to
prevent or cure infections and other pathologies, such as cancer or autoimmune disorders …

Long-acting vaccine delivery systems

P Walvekar, P Kumar, YE Choonara - Advanced Drug Delivery Reviews, 2023 - Elsevier
Bolus vaccines are often administered multiple times due to rapid clearance and reduced
transportation to draining lymph nodes resulting in inadequate activation of T and B …

Evaluating polymeric biomaterials to improve next generation wound dressing design

JG Hodge, DS Zamierowski, JL Robinson… - Biomaterials …, 2022 - spj.science.org
Wound healing is a dynamic series of interconnected events with the ultimate goal of
promoting neotissue formation and restoration of anatomical function. Yet, the complexity of …

Opportunities for biomaterials to address the challenges of COVID‐19

D Chakhalian, RB Shultz, CE Miles… - Journal of Biomedical …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has revealed major
shortcomings in our ability to mitigate transmission of infectious viral disease and provide …

Immunostimulatory DNA Hydrogel Enhances Protective Efficacy of Nanotoxoids against Bacterial Infection

Z Guo, J Zhou, Y Yu, N Krishnan, I Noh… - Advanced …, 2023 - Wiley Online Library
While vaccines have been highly successful in protecting against various infections, there
are still many high‐priority pathogens for which there are no clinically approved …

The foreign body response: emerging cell types and considerations for targeted therapeutics

B Yang, N Rutkowski, J Elisseeff - Biomaterials science, 2023 - pubs.rsc.org
The foreign body response (FBR) remains a clinical challenge in the field of biomaterials
due to its ability to elicit a chronic and sustained immune response. Modulating the immune …

Biomaterials, biological molecules, and polymers in developing vaccines

SP Ravi, Y Shamiya, A Chakraborty, C Elias… - Trends in …, 2021 - cell.com
Vaccines have been used to train the immune system to recognize pathogens, and prevent
and treat diseases, such as cancer, for decades. However, there are continuing challenges …