Fluorinated compounds are synthesized in pharmaceutical research on a routine basis and
many marketed compounds contain fluorine. The present review summarizes some of the …

The trifluoromethyl group (CF3) is an important structural moiety present in diverse classes
of bioactive organic molecules including novel pharmaceuticals and agrochemicals. 1 e4 In …

Glycans are well established to play important roles at various stages of infection and
disease, and ways to modulate these interactions have been sought as novel therapies. The …

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third
edition of this popular textbook remains comprehensive, authoritative and readable. Taking …

Extensive efforts since 1931, on the structural determination of the mammalian tachykinin SP
by NMR, CD and IR have turned out to be inconclusive. Studies are now being concentrated …

An efficient stereoselective synthesis of the orally active NK1 receptor antagonist Aprepitant
is described. A direct condensation of N-benzyl ethanolamine with glyoxylic acid yielded a 2 …

An NH4I-based reductive system has been explored to promote the oxime N–O bond
cleavage and thereby enable a modular synthesis of a broad range of pharmacologically …

This paper describes the synthesis and physical and biological effects of introducing
different substituents at the α-position of the tryptophan containing neurokinin-1 receptor …

A number of fluorinated versatile building blocks (synthons) were developed for the
synthesis of trifluoromethylated and gem-difluoromethylenated biologically interesting …

Through optimization of compounds based on the dual NK1/NK2 antagonist ZD6021, it was
found that alteration of two key regions could modulate the balance of NK1 and NK2 …