Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …
environment or partition cells into distinct compartments. These membranes are lipid …
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …
The ADAM metalloproteinases
DR Edwards, MM Handsley, CJ Pennington - Molecular aspects of …, 2008 - Elsevier
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …
and secreted proteins with important roles in regulating cell phenotype via their effects on …
Targeting ADAM10 in cancer and autoimmunity
TM Smith Jr, A Tharakan, RK Martin - Frontiers in immunology, 2020 - frontiersin.org
Generating inhibitors for AD isintegrin A nd M etalloproteinase 10 (ADAM10), a zinc-
dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 …
dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 …
[HTML][HTML] Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases
Signal peptide peptidase (SPP) and the homologous SPP-like (SPPL) proteases SPPL2a,
SPPL2b, SPPL2c and SPPL3 belong to the family of GxGD intramembrane proteases …
SPPL2b, SPPL2c and SPPL3 belong to the family of GxGD intramembrane proteases …
Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma
Y Fukuda, MA Bustos, SN Cho, J Roszik, S Ryu… - Cell Death & …, 2022 - nature.com
Soluble forms of receptors play distinctive roles in modulating signal-transduction pathways.
Soluble CD74 (sCD74) has been identified in sera of inflammatory diseases and implicated …
Soluble CD74 (sCD74) has been identified in sera of inflammatory diseases and implicated …
The endo-lysosomal system in Parkinson's disease: Expanding the horizon
A Muraleedharan, B Vanderperre - Journal of Molecular Biology, 2023 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …
Multiethnic meta-analysis of genome-wide association studies in> 100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal …
Background—Estimates of the heritability of plasma fibrinogen concentration, an established
predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far …
predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far …
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
Human inborn errors of IFN-γ immunity underlie mycobacterial diseases. We describe
patients with Mycobacterium bovis (BCG) disease who are homozygous for loss-of-function …
patients with Mycobacterium bovis (BCG) disease who are homozygous for loss-of-function …
Nonapoptotic functions of Fas/CD 95 in the immune response
JP Guégan, P Legembre - The FEBS Journal, 2018 - Wiley Online Library
CD 95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR)
superfamily. Its cognate ligand, CD 95L, is implicated in immune homeostasis and immune …
superfamily. Its cognate ligand, CD 95L, is implicated in immune homeostasis and immune …