A disintegrin and metalloproteases (ADAMs) have been implicated in many processes
controlling organismic development and integrity. Important substrates of ADAM proteases …

The sequential processing of single pass transmembrane proteins via ectodomain shedding
followed by intramembrane proteolysis is involved in a wide variety of signaling processes …

The ability of FasL/CD95L to induce apoptosis in various Fas/CD95-expressing cells has
been described in the context of hematopoiesis or thymic elimination of self-reactive T cells …

Intramembrane proteolysis is now widely recognized as an important physiological pathway
required for reverse signaling and membrane protein degradation. Aspartyl intramembrane …

Introduction T cell and NK cell cytotoxicity can be mediated via the perforin/granzyme system
and Fas Ligand (FasL, CD178). FasL is synthesized as a type II transmembrane protein that …

Five genes encode the five human signal peptide peptidases (SPPs), which are
intramembrane-cleaving aspartyl proteases (aspartyl I-CLiPs). SPPs have been conserved …

Intramembrane proteolysis is more than a mechanism to “clean” the membranes from
proteins no longer needed. By non-reversibly modifying transmembrane proteins …

Apoptosis has emerged as a fundamental process important in tissue homeostasis, immune
response, and during development. CD95 (also known as Fas), a member of the tumor …

Abstract The “A Disintegrin And Metalloproteinases”(ADAMs) form a subgroup of the
metzincin endopeptidases. Proteolytically active members of this protein family act as …

Cisplatin, a standard chemotherapeutic agent for many tumors, has an unfortunately
common toxicity where almost a third of patients develop renal dysfunction after a single …