Mitochondrial dysfunction and neurodegeneration underlie movement disorders such as
Parkinson's disease, Huntington's disease and Manganism among others. As a corollary …

Interactions between the TNF-family receptor Fas (CD95) and Fas Ligand (FasL, CD178)
can efficiently induce apoptosis and are critical for the maintenance of immunological self …

Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002
to Sulston, Brenner and Horvitz [1]. Since then it has been clear that alteration of apoptotic …

A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane protein
that functions as a “molecular scissor” to cleave the extracellular regions from its …

More than 20 years ago, signal peptide peptidase (SPP) and its homologues, the signal
peptide peptidase‐like (SPPL) proteases have been identified based on their sequence …

Signal peptide peptidase-like 2 (SPPL) proteases constitute a subfamily of SPP/SPPL
intramembrane proteases which are homologues of the presenilins, the catalytic core of the …

Signal peptide peptidase-like 2a (SPPL2a) is an aspartic intramembrane protease which
has recently been shown to play an important role in the development and function of …

The TNF superfamily member Fas ligand acts as a prototypic death factor. Due to its ability to
induce apoptosis in Fas (APO-1, CD95) expressing cells, Fas ligand participates in essential …

The presenilin homologue signal peptide peptidase-like 2a (SPPL2a) is an intramembrane
protease of lysosomes/late endosomes which cleaves type II transmembrane proteins. We …

The systemic inflammatory response syndrome and subsequent organ failure are mainly
driven by activated neutrophils with prolonged life span, which is believed to be due to …