The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines
expressed in many different cell types including skeletal muscle. Members of this …

In most cases, pharmacologic strategies to treat genetic muscle disorders and certain
acquired disorders, such as sporadic inclusion body myositis, have produced modest …

Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE)
is implicated in geographic atrophy (GA), an advanced form of age-related macular …

Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including
dystrophies of the skeletal muscle and fat, dilated cardiomyopathy, and progeria-like …

Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …

Muscular dystrophy is a group of more than 30 different clinical genetic disorders that are
characterized by progressive skeletal muscle wasting and degeneration. Primary deficiency …

Abstract Background Myostatin (Mstn) and growth/differentiation factor 11 (Gdf11) are highly
related transforming growth factor β (TGFβ) family members that play important roles in …

Muscle wasting disease indications are among the most debilitating and often deadly
noncommunicable disease states. As a comorbidity, muscle wasting is associated with …

M uscle aging is characterized by a decline in functional performance and restriction of
adaptability, due to progressive loss of muscle tissue coupled with a decrease in strength …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …