Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Background Human genetic association studies point to immune response and lipid
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …

Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic
losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, and …

Abstract Metabolism of MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) to the
neurotoxin MPP+ in the brain causes permanent Parkinson's disease-like symptoms by …

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …

This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

Abstract Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system
(CNS), are active players in shaping neuronal circuitry and function. It has become …

Alzheimer's disease (AD) diagnosis is based on invasive and expensive biomarkers.
Regarding AD pathophysiological mechanisms, there is evidence of a link between AD and …