Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of
the central nervous system characterized by immune-mediated myelin and axonal damage …

CNS white matter, the collection of axons and supporting glia of the mammalian CNS,
makes up close to 50% of the human brain by volume. Interruption of vital interconnects …

Axonal pathology is a key contributor to long‐term disability in multiple sclerosis (MS), an
inflammatory demyelinating disease of the central nervous system (CNS), but the …

Spinal cord injury (SCI) is a complex debilitating condition leading to permanent life-long
neurological deficits. The complexity of SCI suggests that a concerted multi-targeted …

Optic neuritis (ON), which is an acute inflammatory autoimmune demyelinating disease of
the central nervous system (CNS), often occurs in multiple sclerosis (MS). ON is an early …

Multiple sclerosis is characterised by inflammatory neurodegeneration, with axonal injury
and neuronal cell death occurring in parallel to demyelination. Regarding the molecular …

Multiple sclerosis (MS) pathology is marked by the massive infiltration of myelin‐specific T
cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro …

Background The cellular prion protein (PrPc) is a host-encoded glycoprotein whose
transconformation into PrP scrapie (PrPSc) initiates prion diseases. The role of PrPc in …

Optic neuritis is a common manifestation of multiple sclerosis, an inflammatory
demyelinating disease of the CNS. Recently, the neurodegenerative component of multiple …

Experimental autoimmune encephalomyelitis (EAE) is an animal model for studying multiple
sclerosis (MS). Calpain has been implicated in many inflammatory and neurodegenerative …