Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage
A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans
B Hwa Yun, J Guo, M Bellamri… - Mass spectrometry …, 2020 - Wiley Online Library
Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …
Extraction of DNA by magnetic ionic liquids: tunable solvents for rapid and selective DNA analysis
DNA extraction represents a significant bottleneck in nucleic acid analysis. In this study,
hydrophobic magnetic ionic liquids (MILs) were synthesized and employed as solvents for …
hydrophobic magnetic ionic liquids (MILs) were synthesized and employed as solvents for …
[HTML][HTML] Mechanistic evidence for red meat and processed meat intake and cancer risk: a follow-up on the international agency for research on cancer evaluation of …
RJ Turesky - Chimia, 2018 - ncbi.nlm.nih.gov
Abstract The Working Group of the International Agency for Research on Cancer classified
the consumption of processed meat as carcinogenic to humans (Group 1), and classified red …
the consumption of processed meat as carcinogenic to humans (Group 1), and classified red …
Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts
Exogenous and endogenous sources of chemical species can react, directly or after
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …
Mass spectrometry of structurally modified DNA
Structural modifications of nucleobases within the deoxyribonucleic acid (DNA) of living cells
can be induced as a result of actions of specialized DNA-modifying enzymes (creating …
can be induced as a result of actions of specialized DNA-modifying enzymes (creating …
The variety of UV-induced pyrimidine dimeric photoproducts in DNA as shown by chromatographic quantification methods
T Douki - Photochemical & Photobiological Sciences, 2013 - pubs.rsc.org
Induction of DNA damage is one of the major consequences of exposure to solar UV
radiation in living organisms. UV-induced DNA photoproducts are mostly pyrimidine dimers …
radiation in living organisms. UV-induced DNA photoproducts are mostly pyrimidine dimers …
Mass spectrometry analysis of DNA and protein adducts as biomarkers in human exposure to cigarette smoking: acrolein as an example
HJC Chen - Chemical Research in Toxicology, 2023 - ACS Publications
Acrolein is a major component in cigarette smoke and a product of endogenous lipid
peroxidation. It is difficult to distinguish human exposure to acrolein from exogenous sources …
peroxidation. It is difficult to distinguish human exposure to acrolein from exogenous sources …
Mitochondrial DNA damage: prevalence, biological consequence, and emerging pathways
L Zhao, P Sumberaz - Chemical research in toxicology, 2020 - ACS Publications
Mitochondria have a plethora of functions within a eukaryotic cell, ranging from energy
production, cell signaling, and protein cofactor synthesis to various aspects of metabolism …
production, cell signaling, and protein cofactor synthesis to various aspects of metabolism …
[HTML][HTML] Chemical analysis of DNA damage
In human cells, the integrity of genetic information is constantly challenged by endogenous
and exogenous chemical agents that can induce DNA damage. To counteract the …
and exogenous chemical agents that can induce DNA damage. To counteract the …