Cells are constantly exposed to various sources of DNA damage that pose a threat to their
genomic integrity. One of the most common types of DNA breaks are single-strand breaks …

DNA adducts are a measure of internal exposure to genotoxicants. However, the
measurement of DNA adducts in molecular epidemiology studies often is precluded by the …

2-Amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP), a carcinogenic heterocyclic
aromatic amine formed in cooked meats, is metabolically activated to electrophilic …

This article proposes a practical guide including good laboratory practices followed by a
critical review about applications of isotope dilution mass spectrometry measurement (ID …

The concept of the exposome is the encompassing of all the environmental exposures, both
exogenous and endogenous, across the life course. Many, if not all, of these exposures can …

DNA mutations can result from replication errors due to different forms of DNA damage,
including low-abundance DNA adducts induced by reactions with electrophiles. The lack of …

Cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6–4) pyrimidone photoproducts (6–
4PPs) are genotoxic DNA lesions and mainly generated on thymine–thymine (T–T) …

Abstract Poly (ADP-ribosyl) ation (PARylation), ie, the formation of the nucleic acid-like
biopolymer poly (ADP-ribose)(PAR), is an essential posttranslational modification carried …

Humans are continuously exposed to hazardous chemicals in the environment. These
chemicals or their electrophilic metabolites can form adducts with genomic DNA, which can …

Glyoxal (gx) is a bifunctional electrophile capable of cross-linking DNA. Although it is
present in foods and from the environment, endogenous formation of glyoxal occurs through …