Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging haemorrhagic fever
that was first described in rural areas of China. The causative agent, SFTS virus (SFTSV), is …

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

Fibrosis is an intrinsic response to chronic injury, maintaining organ integrity when extensive
necrosis or apoptosis occurs. With protracted damage, fibrosis can progress toward …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile illness
characterized by fever, leukopenia, thrombocytopenia, and gastrointestinal symptoms such …

Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality
and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is …

Objective Monocyte chemoattractant protein-1 (MCP-1, CCL2), the primary ligand for
chemokine receptor C–C chemokine receptor 2 (CCR2), is increased in livers of patients …

BACKGROUND & AIMS: Activated hepatic stellate cells (HSCs), the main fibrogenic cell type
in the liver, undergo apoptosis after cessation of liver injury, which contributes to resolution …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …