Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS
TE Faust, G Gunner, DP Schafer - Nature Reviews Neuroscience, 2021 - nature.com
Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
Psychotic disorders
JA Lieberman, MB First - New England Journal of Medicine, 2018 - Mass Medical Soc
Psychosis Psychosis is a syndrome embedded in several disorders, including schizophrenia
and bipolar disorder with psychotic features. Dopamine and glutamate are implicated in the …
and bipolar disorder with psychotic features. Dopamine and glutamate are implicated in the …
Transplanted embryonic neurons integrate into adult neocortical circuits
S Falkner, S Grade, L Dimou, KK Conzelmann… - Nature, 2016 - nature.com
The ability of the adult mammalian brain to compensate for neuronal loss caused by injury or
disease is very limited. Transplantation aims to replace lost neurons, but the extent to which …
disease is very limited. Transplantation aims to replace lost neurons, but the extent to which …
Synaptic elimination in neurological disorders
PL Cardozo, I de Lima, E Maciel… - Current …, 2019 - ingentaconnect.com
Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …
[HTML][HTML] Major histocompatibility complex (MHC) genes and disease resistance in fish
T Yamaguchi, JM Dijkstra - Cells, 2019 - mdpi.com
Fascinating about classical major histocompatibility complex (MHC) molecules is their
polymorphism. The present study is a review and discussion of the fish MHC situation. The …
polymorphism. The present study is a review and discussion of the fish MHC situation. The …
[HTML][HTML] Isochronic development of cortical synapses in primates and mice
The neotenous, or delayed, development of primate neurons, particularly human ones, is
thought to underlie primate-specific abilities like cognition. We tested whether synaptic …
thought to underlie primate-specific abilities like cognition. We tested whether synaptic …
Mechanisms of microglia-mediated synapse turnover and synaptogenesis
JB Ball, SM Green-Fulgham, LR Watkins - Progress in Neurobiology, 2022 - Elsevier
Microglia shape synaptic connections among neurons of the central nervous system (CNS)
during development and adulthood. In this review, the actions by which they facilitate …
during development and adulthood. In this review, the actions by which they facilitate …
Exogenous Hsp70 delays senescence and improves cognitive function in aging mice
NV Bobkova, M Evgen'ev, DG Garbuz… - Proceedings of the …, 2015 - National Acad Sciences
Molecular chaperone Heat Shock Protein 70 (Hsp70) plays an important protective role in
various neurodegenerative disorders often associated with aging, but its activity and …
various neurodegenerative disorders often associated with aging, but its activity and …
Redox and immune signaling in schizophrenia: new therapeutic potential
D Dwir, I Khadimallah, L Xin, M Rahman… - International Journal …, 2023 - academic.oup.com
Redox biology and immune signaling play major roles in the body, including in brain
function. A rapidly growing literature also suggests that redox and immune abnormalities are …
function. A rapidly growing literature also suggests that redox and immune abnormalities are …
Dendritic spine elimination: molecular mechanisms and implications
IS Stein, K Zito - The Neuroscientist, 2019 - journals.sagepub.com
Dynamic modification of synaptic connectivity in response to sensory experience is a vital
step in the refinement of brain circuits as they are established during development and …
step in the refinement of brain circuits as they are established during development and …