Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the
factors that make life difficult with aging, and on the other side are the products of human …

Ischemic stroke is an acute and serious cerebral vascular disease, which greatly affects
people's health and brings huge economic burden to society. Microglia, as important innate …

Ischemic stroke is one of the leading causes of death, and even timely treatment can result
in severe disabilities. Reperfusion of the ischemic stroke region and restoration of the blood …

Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and
mortality, any treatment targeting a single session is insufficient to tackle this. CHF is …

Myocardial ischemia-reperfusion injury (MI/RI) seriously restricts the therapeutic effect of
reperfusion. It is demonstrated that ferroptosis and apoptosis of cardiomyocytes are widely …

In clinical organ transplantation, donor and recipient ages may differ substantially. Old donor
organs accumulate senescent cells that have the capacity to induce senescence in naïve …

Tanshinone IIA (TSN) extracted from danshen (Salvia miltiorrhiza) could protect
cardiomyocytes against myocardial ischemia/reperfusion injury (IRI), however the …

Efferocytosis is defined as the clearance of apoptotic cells (ACs) in physiological and
pathological states and is performed by efferocytes, such as macrophages. Efferocytosis can …

Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence
indicates that biological aging has a significant effect on the onset and progression of CVDs …