The actions of androgens such as testosterone and dihydrotestosterone are mediated via
the androgen receptor (AR), a ligand-dependent nuclear transcription factor and member of …

The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and
the support of male sexual-related functions, as well as in the progression of prostate …

Background Multiple loss-of-function alterations in genes that are involved in DNA repair,
including homologous recombination repair, are associated with response to poly …

BACKGROUND: Most personalized cancer care strategies involving DNA sequencing are
highly reliant on acquiring sufficient fresh or frozen tissue. It has been challenging to …

Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this
study, we investigated the role and association of epithelial–mesenchymal transition (EMT) …

Prostate-specific membrane antigen (PSMA) is a type II integral membrane protein
expressed on the surface of prostate cancer (PCa) cells, particularly in androgen …

Challenges in recognizing treatment-related neuroendocrine prostate cancer. - Abstract -
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Prostate cancer (CaP) is the second leading malignancy in men. The role of epithelial cell
adhesion molecule (EpCAM), also known as CD326, in CaP progression and therapeutic …

The current paradigm of cancer care relies on predictive nomograms which integrate
detailed histopathology with clinical data. However, when predictions fail, the consequences …

Abstract The PI3K/AKT/mTOR pathway is frequently activated in advanced prostate cancer,
due to loss of the tumour suppressor PTEN, and is an important axis for drug development …