Plasticity and homeostatic mechanisms allow neural networks to maintain proper function
while responding to physiological challenges. Despite previous work investigating …

Objective. The purpose of this study is to investigate whether and how the balance between
excitation and inhibition ('E/I balance') influences the spontaneous development of human …

Motivated by the unexplored potential of in vitro neural systems for computing and by the
corresponding need of versatile, scalable interfaces for multimodal interaction, an accurate …

Neuronal cultures are one of the most important experimental models in modern
interdisciplinary neuroscience, allowing to investigate in a control environment the …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to
Parkinson's disease, where the G2019S variant has been shown to contribute uniquely to …

In vitro models of neuronal networks have emerged as a potent instrument for gaining
deeper insights into the intricate mechanisms governing the human brain. Notably, the …

Abstract Characterization and modeling of biological neural networks has emerged as a
field driving significant advancements in our understanding of brain function and related …

Three-dimensional (3D) neuronal cultures are valuable models for studying brain complexity
in vitro, and the choice of the bulk material in which the neurons grow is a crucial factor in …

Persistent global synchronization within a neuronal network is generally considered an
undesirable, pathological state that often arises from to the loss of regulatory neurons or …

Three-dimensional (3D) neuronal cultures grown in hydrogels are promising platforms to
design brain-like neuronal networks in vitro. However, the optimal properties of such …