Translating IL-6 biology into effective treatments
EH Choy, F De Benedetti, T Takeuchi… - Nature Reviews …, 2020 - nature.com
Abstract In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is
important for antibody production by B cells. Since its discovery more than 40 years ago, the …
important for antibody production by B cells. Since its discovery more than 40 years ago, the …
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
MD Giraldez, D Carneros, C Garbers… - Nature reviews …, 2021 - nature.com
IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …
Interleukin‐31: The “itchy” cytokine in inflammation and therapy
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
Targeting interleukin-6 in inflammatory autoimmune diseases and cancers
X Yao, J Huang, H Zhong, N Shen, R Faggioni… - Pharmacology & …, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …
Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses
T Jostock, J Müllberg, S Özbek, R Atreya… - European journal of …, 2001 - Wiley Online Library
Signal transduction in response to interleukin‐6 (IL‐6) requires binding of the cytokine to its
receptor (IL‐6R) and subsequent homodimerization of the signal transducer gp130. The …
receptor (IL‐6R) and subsequent homodimerization of the signal transducer gp130. The …
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation
J Berkes, VK Viswanathan, SD Savkovic, G Hecht - Gut, 2003 - gut.bmj.com
The effects of pathogenic organisms on host intestinal epithelial cells are vast. Innumerable
signalling pathways are triggered leading ultimately to drastic changes in physiological …
signalling pathways are triggered leading ultimately to drastic changes in physiological …
Characteristics of intestinal dendritic cells in inflammatory bowel diseases
Background & Aims: Dendritic cells (DCs) recognize and respond to microbial structures
using pattern recognition receptors, including Toll-like receptors (TLRs). In the intestine, DCs …
using pattern recognition receptors, including Toll-like receptors (TLRs). In the intestine, DCs …
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
H Ito, M Takazoe, Y Fukuda, T Hibi, K Kusugami… - Gastroenterology, 2004 - Elsevier
Background & Aims: Interleukin-6 (IL-6) regulates immune response and inflammation. We
carried out a pilot placebo-controlled study to investigate the efficacy, pharmacokinetics, and …
carried out a pilot placebo-controlled study to investigate the efficacy, pharmacokinetics, and …
Novel targeted therapies for inflammatory bowel disease
M Coskun, S Vermeire, OH Nielsen - Trends in pharmacological sciences, 2017 - cell.com
Our growing understanding of the immunopathogenesis of inflammatory bowel disease
(IBD) has opened new avenues for developing targeted therapies. These advances in …
(IBD) has opened new avenues for developing targeted therapies. These advances in …
Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer
R Atreya, MF Neurath - Clinical reviews in allergy & immunology, 2005 - Springer
Inflammatory bowel disease (IBD), which consists of Crohn's disease and ulcerative colitis,
is defined as a chronic inflammation of the gastrointestinbal tract. The etiopathogenetic …
is defined as a chronic inflammation of the gastrointestinbal tract. The etiopathogenetic …