Abstract In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is
important for antibody production by B cells. Since its discovery more than 40 years ago, the …

IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …

The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Signal transduction in response to interleukin‐6 (IL‐6) requires binding of the cytokine to its
receptor (IL‐6R) and subsequent homodimerization of the signal transducer gp130. The …

The effects of pathogenic organisms on host intestinal epithelial cells are vast. Innumerable
signalling pathways are triggered leading ultimately to drastic changes in physiological …

Background & Aims: Dendritic cells (DCs) recognize and respond to microbial structures
using pattern recognition receptors, including Toll-like receptors (TLRs). In the intestine, DCs …

Background & Aims: Interleukin-6 (IL-6) regulates immune response and inflammation. We
carried out a pilot placebo-controlled study to investigate the efficacy, pharmacokinetics, and …

Our growing understanding of the immunopathogenesis of inflammatory bowel disease
(IBD) has opened new avenues for developing targeted therapies. These advances in …

Inflammatory bowel disease (IBD), which consists of Crohn's disease and ulcerative colitis,
is defined as a chronic inflammation of the gastrointestinbal tract. The etiopathogenetic …