The heart is constantly under stress and cardiomyocytes face enormous challenges to
correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the …

Over the past decade, the role of the ubiquitin–proteasome system (UPS) has been the
subject of numerous studies to elucidate its role in cardiovascular physiology and …

p53 plays an important role in regulating apoptosis. However, the molecular mechanism by
which it initiates the apoptotic program still remains to be fully understood. Here, we report …

Adriamycin, a widely used anthracycline antibiotic in multiple chemotherapy regimens, has
been challenged by the cardiotoxicity leading to fatal congestive heart failure in the worst …

Purpose P53 is one of the key tumor suppressors. In normal cells, p53 is maintained at low
levels by the ubiquitination of the ubiquitinated ligase MDM2. In contrast, under stress …

The ubiquitin proteasome system (UPS) is the major pathway for intracellular protein
degradation in most organs, including the heart. UPS controls many fundamental biological …

The ubiquitin-proteasome system (UPS) plays a central role in protein degradation and
regulates a variety of critical cellular processes. During recent years, the cardiac UPS has …

The most common cause of systolic dysfunction in the United States is prior ischemic injury.
As the basic functional unit of the myocardium, the cardiac myocyte is the ultimate target of …

Apoptosis repressor with caspase recruitment domain (ARC) is a highly effective and
multifunctional inhibitor of apoptosis that is mainly expressed in postmitotic cells such as …

To better understand how the apoptosis repressor with caspase recruitment domain (ARC)
protein confers drug resistance in acute myeloid leukemia (AML), we investigated the role of …