Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity
and overlapping symptoms. However, the causative mechanisms underlying this …
and overlapping symptoms. However, the causative mechanisms underlying this …
Mapping genetic effects on cellular phenotypes with “cell villages”
JM Mitchell, J Nemesh, S Ghosh, RE Handsaker… - Biorxiv, 2020 - biorxiv.org
Tens of thousands of genetic variants shape human phenotypes, mostly by unknown cellular
mechanisms. Here we describe Census-seq, a way to measure cellular phenotypes in cells …
mechanisms. Here we describe Census-seq, a way to measure cellular phenotypes in cells …
Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci
Kleine-Levin syndrome (KLS) is a rare disorder characterized by severe episodic
hypersomnia, with cognitive impairment accompanied by apathy or disinhibition …
hypersomnia, with cognitive impairment accompanied by apathy or disinhibition …
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
Migraine is three times more prevalent in people with bipolar disorder or depression. The
relationship between schizophrenia and migraine is less certain although glutamatergic and …
relationship between schizophrenia and migraine is less certain although glutamatergic and …
Exploring the relationship between schizophrenia and cardiovascular disease: a genetic correlation and multivariable Mendelian randomization study
RR Veeneman, JM Vermeulen… - Schizophrenia …, 2022 - academic.oup.com
Individuals with schizophrenia have a reduced life-expectancy compared to the general
population, largely due to an increased risk of cardiovascular disease (CVD). Clinical and …
population, largely due to an increased risk of cardiovascular disease (CVD). Clinical and …
[PDF][PDF] Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model
Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
Proteome-wide association study provides insights into the genetic component of protein abundance in psychiatric disorders
J Liu, X Li, XJ Luo - Biological psychiatry, 2021 - Elsevier
Background Genome-wide association studies have identified multiple risk variants for
psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders …
psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders …
The emerging field of polygenic risk scores and perspective for use in clinical care
Genetic testing is used widely for diagnostic, carrier and predictive testing in monogenic
diseases. Until recently, there were no genetic testing options available for multifactorial …
diseases. Until recently, there were no genetic testing options available for multifactorial …
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
The most significant common variant association for schizophrenia (SCZ) reflects increased
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
Ancestry: How researchers use it and what they mean by it
Background: Ancestry is often viewed as a more objective and less objectionable population
descriptor than race or ethnicity. Perhaps reflecting this, usage of the term “ancestry” is …
descriptor than race or ethnicity. Perhaps reflecting this, usage of the term “ancestry” is …