De novo mutations and copy number deletions in NRXN1 (2p16. 3) pose a significant risk for
schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical development in a …

Genome-wide association studies (GWASs) have detected many susceptible variants for
common diseases, including psychiatric disorders. However, because of the small effect size …

Genetic testing has evolved rapidly over recent years and new developments have the
potential to provide insights that could improve the ability to diagnose, treat, and prevent …

Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a
lifetime of chronic disability, causing devastating personal and economic consequences …

Background Humans and viruses have co-evolved for millennia resulting in a complex host
genetic architecture. Understanding the genetic mechanisms of immune response to viral …

Polygenic scores offer developmental psychologists new methods for integrating genetic
information into research on how people change and develop across the life span. Indeed …

Background Epidemiological and clinical studies have suggested comorbidity between
frontotemporal dementia (FTD) and psychiatric disorders. FTD patients carrying specific …

Sleep duration has been linked to a wide range of negative health outcomes and to reduced
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …

Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in
schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are …

Admixed populations constitute a large portion of global human genetic diversity, yet they
are often left out of genomics analyses. This exclusion is problematic, as it leads to …