IL-18-mediated neutrophil recruitment promotes acute lung injury in inflammation-mediated chronic pancreatitis

HK Kandikattu, SU Venkateshaiah, S Kumar… - Molecular …, 2023 - Elsevier
Lung injury is the most common secondary complication of pancreatitis and pancreatic
malignancy. Around 60–70% of pancreatitis-related deaths are caused by lung injury; …

Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis

F Kong, Y Pan, D Wu - Biomedicines, 2024 - mdpi.com
In the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs)
emerge as central figures. These cells, initially in a dormant state characterized by the …

Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function

RS Kalsi, AM Kreger, M Saleh, S Yoshida, K Sharma… - Scientific Reports, 2023 - nature.com
Chronic pancreatitis is a debilitating disease affecting millions worldwide. These patients
suffer from bouts of severe pain that are minimally relieved by pain medications and may …

Risk Factors of Pancreatic Cancer: A Literature Review

T Ke, A Lophatananon, M Nieroda… - Cancer Reports and …, 2022 - discovery.ucl.ac.uk
Objective: To identify and compare current modifiable and non-modifiable risk factors for
pancreatic cancer (PaCa) that may have potential application in PaCa risk stratification …

Correlation between Pancreatic Duct Variation and Related Diseases: An Effective Method Observing the Dual-Energy CT with Low-keV Monoenergetic Images

R Zhang, Z Li, X Hu, H Liang, G Yan, D Xie, J Zhang… - Diagnostics, 2023 - mdpi.com
Purpose: Pancreatic duct variation can affect the secretory function of the pancreas. We
aimed to explore the pancreatic duct variation, observed using low-keV monoenergetic …

Salivary Biomarker Evaluation of Chronic Pancreatitis Patients Reveals Alterations in Human Proteins, Cytokines, Prostaglandin E2 Levels, and Bacterial Diversity

RT Waldron, EK Jones, VI Anani, JM Hines, J Zhao… - Pancreas, 2022 - journals.lww.com
Objectives Chronic pancreatitis (CP) is a chronic fibroinflammatory condition of the pancreas
difficult to diagnose in early stages. Novel biomarkers useful to facilitate early diagnosis or …

Chronic inflammation promotes epithelial-mesenchymal transition-mediated malignant phenotypes and lung injury in experimentally-induced pancreatitis

HK Kandikattu, M Manohar, SU Venkateshaiah… - Life sciences, 2021 - Elsevier
Patients with chronic pancreatitis have an increased risk of pancreatic malignancy, but the
mechanisms underlying this relationship are poorly understood. We developed a mouse …

Pancreatic stellate cells: Key players in pancreatic health and diseases

Z Wang, S Dong, W Zhou - Molecular Medicine …, 2024 - spandidos-publications.com
As a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various
pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the …

Diagnostic Differentiation between Pancreatitis and Pancreatic Cancer: A Scoping Review

F Madela, L Ferndale, C Aldous - Diagnostics, 2024 - mdpi.com
Pancreatitis, encompassing acute and chronic forms, and pancreatic cancer pose significant
challenges to the exocrine tissue of the pancreas. Recurrence rates and complications …

[HTML][HTML] Close relationship between mediators of inflammation and pancreatic cancer: Our experience

F Vescio, M Ammendola, G Currò… - World Journal of …, 2024 - wjgnet.com
In this editorial, we focus specifically on the mechanisms by which pancreatic inflammation
affects pancreatic cancer. Cancer of the pancreas remains one of the deadliest cancer types …