Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and …

D Mokra, M Joskova, J Mokry - International journal of molecular sciences, 2022 - mdpi.com
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

Targeting innate immunity-driven inflammation in CKD and cardiovascular disease

T Speer, S Dimmeler, SJ Schunk, D Fliser… - Nature Reviews …, 2022 - nature.com
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Systemic immune-inflammation index is associated with increased urinary albumin excretion: a population-based study

Z Qin, H Li, L Wang, J Geng, Q Yang, B Su… - Frontiers in …, 2022 - frontiersin.org
Background Systemic immune-inflammation index (SII) is a novel inflammatory marker, and
inflammation has been reported to be related with renal damage. We aimed to investigate …

The role of inflammation in CKD

SP Kadatane, M Satariano, M Massey, K Mongan… - Cells, 2023 - mdpi.com
Chronic kidney disease (CKD) affects many adults worldwide. Persistent low-grade
inflammation is a substantial factor in its development and progression and has correlated …

Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives

DM Tanase, EM Gosav, MI Anton, M Floria… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

Klotho, oxidative stress, and mitochondrial damage in kidney disease

J Donate-Correa, B Martín-Carro, JB Cannata-Andía… - Antioxidants, 2023 - mdpi.com
Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

Short-chain fatty acids in chronic kidney disease: Focus on inflammation and oxidative stress regulation

G Magliocca, P Mone, BR Di Iorio, A Heidland… - International Journal of …, 2022 - mdpi.com
Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary
complications that increase comorbidity and mortality. In patients with CKD, there is a …

Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease

MY Wang, Z Zhang, S Zhao, T Onodera, XN Sun, Q Zhu… - Cell metabolism, 2024 - cell.com
The glucagon receptor (GCGR) in the kidney is expressed in nephron tubules. In humans
and animal models with chronic kidney disease, renal GCGR expression is reduced …

Folic acid‐induced animal model of kidney disease

LJ Yan - Animal models and experimental medicine, 2021 - Wiley Online Library
The kidneys are a vital organ that is vulnerable to both acute kidney injury (AKI) and chronic
kidney disease (CKD) which can be caused by numerous risk factors such as ischemia …

Recent advances in understanding Nrf2 agonism and its potential clinical application to metabolic and inflammatory diseases

MJ Kim, JH Jeon - International Journal of Molecular Sciences, 2022 - mdpi.com
Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …