Sickle cell disease: a paradigm for venous thrombosis pathophysiology

MA Lizarralde-Iragorri, AS Shet - International journal of molecular …, 2020 - mdpi.com
Venous thromboembolism (VTE) is an important cause of vascular morbidity and mortality.
Many risk factors have been identified for venous thrombosis that lead to alterations in blood …

Tissue factor and extracellular vesicles: activation of coagulation and impact on survival in cancer

Y Hisada, N Mackman - Cancers, 2021 - mdpi.com
Simple Summary The tissue factor (TF)-factor VIIa complex is the major physiological
initiator of blood coagulation. Tumors express TF and release TF-positive extracellular …

Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor–tissue factor axis

M Belghasem, D Roth, S Richards… - Blood, The Journal …, 2019 - ashpublications.org
Patients with malignancy are at 4-to 7-fold higher risk of venous thromboembolism (VTE), a
potentially fatal, yet preventable complication. Although general mechanisms of thrombosis …

Role of microRNAs in venous thromboembolism

VM Morelli, SK Brækkan, JB Hansen - International Journal of Molecular …, 2020 - mdpi.com
MicroRNAs (miRNAs) are non-coding RNAs that execute their function by targeted
downregulation of gene expressions. There is growing evidence from epidemiological …

Role of bone marrow mononuclear cell seeding for nanofiber vascular grafts

T Fukunishi, CA Best, CS Ong, T Groehl… - … Engineering Part A, 2018 - liebertpub.com
Objective: Electrospinning is a promising technology that provides biodegradable nanofiber
scaffolds for cardiovascular tissue engineering. However, success with these materials has …

Time-dependent hardening of blood clots quantitatively measured in vivo with shear-wave ultrasound imaging in a rabbit model of venous thrombosis

E Mfoumou, J Tripette, M Blostein, G Cloutier - Thrombosis research, 2014 - Elsevier
Objective Provide in vivo blood clot hardening evolution with ultrasound using supersonic
imaging of shear waves. Methods We conducted a prospective study in flow stasis-induced …

[HTML][HTML] Animal models of venous thrombosis

H Albadawi, AA Witting, Y Pershad… - Cardiovascular …, 2017 - ncbi.nlm.nih.gov
Venous thrombosis (VT) is a prevalent clinical condition with significant adverse sequela or
mortality. Anticoagulation and pharmacologic or pharmacomechanical thrombolytic …

IL-17A promotes the formation of deep vein thrombosis in a mouse model

P Ding, S Zhang, M Yu, Y Feng, Q Long, H Yang… - International …, 2018 - Elsevier
Deep venous thrombosis (DVT) is a significant problem in the health care industry
worldwide. However, the factors and signaling pathways that trigger DVT formation are still …

Ly6CLo monocyte/macrophages are essential for thrombus resolution in a murine model of venous thrombosis

AS Kimball, AT Obi, CE Luke… - Thrombosis and …, 2020 - thieme-connect.com
Venous thrombosis (VT) resolution is a complex process, resembling sterile wound healing.
Infiltrating blood-derived monocyte/macrophages (Mo/MΦs) are essential for the regulation …

The role of valve stiffness in the insurgence of deep vein thrombosis

Z Schofield, HA Baksamawi, J Campos… - Communications …, 2020 - nature.com
Deep vein thrombosis is a life-threatening development of blood clots in deep veins.
Immobility and blood flow stagnancy are typical risk factors indicating that fluid dynamics …