Noninvasive magnetic resonance imaging measures of glymphatic system activity

K Kamagata, Y Saito, C Andica… - Journal of Magnetic …, 2024 - Wiley Online Library
The comprehension of the glymphatic system, a postulated mechanism responsible for the
removal of interstitial solutes within the central nervous system (CNS), has witnessed …

Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson's disease

T Shen, Y Yue, F Ba, T He, X Tang, X Hu, J Pu… - npj Parkinson's …, 2022 - nature.com
The brain glymphatic system is involved in the clearance of misfolding α-synuclein, the
impaired glymphatic system may contribute to the progression of Parkinson's disease (PD) …

A critical guide to the automated quantification of perivascular spaces in magnetic resonance imaging

W Pham, M Lynch, G Spitz, T O'Brien… - Frontiers in …, 2022 - frontiersin.org
The glymphatic system is responsible for waste clearance in the brain. It is comprised of
perivascular spaces (PVS) that surround penetrating blood vessels. These spaces are filled …

Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease

J Wang, X Wang, H Li, L Shi, N Song, J Xie - Ageing Research Reviews, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease with a global burden
that affects more often in the elderly. The basal ganglia (BG) is believed to account for …

Perivascular spaces mediate a relationship between diabetes and other cerebral small vessel disease markers in cerebrovascular and neurodegenerative diseases

J Zebarth, R Kamal, G Perlman, M Ouk… - Journal of Stroke and …, 2023 - Elsevier
Type 2 diabetes mellitus (T2DM) and hypertension are risk factors for cerebral small vessel
disease (SVD); however, few studies have characterised their relationships with MRI-visible …

Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson's Disease

EK Donahue, RP Foreman, JJ Duran… - Brain Imaging and …, 2024 - Springer
Abstract Perivascular spaces (PVS), fluid-filled compartments surrounding brain vasculature,
are an essential component of the glymphatic system responsible for transport of waste and …

Interplay between the glymphatic system and neurotoxic proteins in Parkinson's disease and related disorders: current knowledge and future directions

Y Yue, X Zhang, W Lv, HY Lai… - Neural Regeneration …, 2024 - journals.lww.com
Parkinson's disease is a common neurodegenerative disorder that is associated with
abnormal aggregation and accumulation of neurotoxic proteins, including α-synuclein …

Experimental models to study immune dysfunction in the pathogenesis of Parkinson's disease

J Saponjic, R Mejías, N Nikolovski, M Dragic… - International journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a chronic, age-related, progressive multisystem disease
associated with neuroinflammation and immune dysfunction. This review discusses the …

[HTML][HTML] The glymphatic system and multiple sclerosis: An evolving connection

A Alghanimy, LM Work, WM Holmes - Multiple Sclerosis and Related …, 2024 - Elsevier
Multiple sclerosis (MS) is a complex autoimmune disorder that affects the central nervous
system, resulting in demyelination and an array of neurological manifestations. Recently …

Altered perivascular spaces in subcortical white matter in Parkinson's disease patients with levodopa-induced dyskinesia

X Cao, C Gan, H Zhang, Y Yuan, H Sun… - npj Parkinson's …, 2024 - nature.com
Dilated perivascular spaces (PVS) have emerged as a pathological hallmark in various
neurological conditions, including Parkinson's disease (PD). Levodopa-induced dyskinesia …