Breast cancer has the highest incidence and death rate among cancers in women
worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and …

Estrogen receptor α (ERα) is closely associated with both hormone-dependent and hormone-
independent tumors, and it is also essential for the development of these cancers. The …

Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we
uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen …

Breast cancer is the most common malignancy in women around the world. Estrogen
receptor α (ERα) is expressed in approximately 70% of breast tumors, and considered as …

As a member of the TRIM (tripartite motif) protein family, TRIM56 can function as an E3
ubiquitin ligase. In addition, TRIM56 has been shown to possess deubiquitinase activity and …

Simple Summary Estrogen receptor-positive (ER+) breast cancer is a notable cause of
global death from breast cancer in premenopausal and postmenopausal women. Lethality is …

Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in
patients with estrogen receptor-positive (ER+) breast cancer. Thus, identifying novel ERα …

Background The tripartite motif (TRIM) family of proteins plays a key role in the
developmental growth and therapeutic resistance of many tumors. However, the regulatory …

Breast cancer has the highest incidence and mortality in women worldwide. There are 70%
of breast cancers considered as estrogen receptor α (ERα) positive. Therefore, the ERα …