Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
EM Goldberg, DA Coulter - Nature Reviews Neuroscience, 2013 - nature.com
Epilepsy is a prevalent neurological disorder associated with significant morbidity and
mortality, but the only available drug therapies target its symptoms rather than the underlying …
mortality, but the only available drug therapies target its symptoms rather than the underlying …
[HTML][HTML] Regulation of adult neurogenesis in mammalian brain
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
Epilepsy, antiepileptic drugs, and aggression: an evidence-based review
Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …
Epilepsy is a neurological and a systemic disorder
The basic pathophysiology of epilepsy is still not fully understood. Epidemiological evidence
for epilepsy seems to suggest that it may not only be the propensity for seizures to occur …
for epilepsy seems to suggest that it may not only be the propensity for seizures to occur …
[HTML][HTML] Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis
RL Williams-Karnesky, US Sandau… - The Journal of …, 2013 - Am Soc Clin Investig
Epigenetic modifications, including changes in DNA methylation, lead to altered gene
expression and thus may underlie epileptogenesis via induction of permanent changes in …
expression and thus may underlie epileptogenesis via induction of permanent changes in …
[HTML][HTML] Deep sequencing reveals increased DNA methylation in chronic rat epilepsy
Epilepsy is a frequent neurological disorder, although onset and progression of seizures
remain difficult to predict in affected patients, irrespective of their epileptogenic condition …
remain difficult to predict in affected patients, irrespective of their epileptogenic condition …
Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy
Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …
Can we 'seize'the gut microbiota to treat epilepsy?
C De Caro, LF Iannone, R Citraro, P Striano… - Neuroscience & …, 2019 - Elsevier
The gut-microbiota, the complex intestinal microbial ecosystem essential to health, is an
emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain …
emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain …
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats
TA Lusardi, KK Akula, SQ Coffman, DN Ruskin… - …, 2015 - Elsevier
Epilepsy is a highly prevalent seizure disorder which tends to progress in severity and
become refractory to treatment. Yet no therapy is proven to halt disease progression or to …
become refractory to treatment. Yet no therapy is proven to halt disease progression or to …
[HTML][HTML] Crosstalk among epigenetic pathways regulates neurogenesis
EM Jobe, AL McQuate, X Zhao - Frontiers in neuroscience, 2012 - frontiersin.org
The process of neurogenesis includes neural stem cell proliferation, fate specification,
young neuron migration, neuronal maturation, and functional integration into existing …
young neuron migration, neuronal maturation, and functional integration into existing …