Epilepsy is a prevalent neurological disorder associated with significant morbidity and
mortality, but the only available drug therapies target its symptoms rather than the underlying …

Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

The basic pathophysiology of epilepsy is still not fully understood. Epidemiological evidence
for epilepsy seems to suggest that it may not only be the propensity for seizures to occur …

Epigenetic modifications, including changes in DNA methylation, lead to altered gene
expression and thus may underlie epileptogenesis via induction of permanent changes in …

Epilepsy is a frequent neurological disorder, although onset and progression of seizures
remain difficult to predict in affected patients, irrespective of their epileptogenic condition …

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …

The gut-microbiota, the complex intestinal microbial ecosystem essential to health, is an
emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain …

Epilepsy is a highly prevalent seizure disorder which tends to progress in severity and
become refractory to treatment. Yet no therapy is proven to halt disease progression or to …

The process of neurogenesis includes neural stem cell proliferation, fate specification,
young neuron migration, neuronal maturation, and functional integration into existing …