Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

Chemical synapses are commonly known as a structurally and functionally highly diverse
class of cell-cell contacts specialized to mediate communication between neurons. They …

Neural circuit function depends on the pattern of synaptic connections between neurons and
the strength of those connections. Synaptic strength is determined by both postsynaptic …

The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and
synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct …

Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain
reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar …

The calyx of Held, a large glutamatergic presynaptic terminal in the auditory brainstem
undergoes developmental changes to support the high action-potential firing rates required …

The Ca 2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are
fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite …

Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and
responsive communication in neural circuits. In this study, we investigated the contributions …

Microtubule‐associated protein tau is a central factor in Alzheimer's disease and other
tauopathies. However, the physiological functions of tau are unclear. Here, we used …

Synaptic transmission and plasticity are shaped by the dynamic reorganization of signaling
molecules within pre-and postsynaptic compartments. The nanoscale organization of key …