The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Background & Objective: Cannabis is one of the earliest cultivated plants. Cannabis of
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …

Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and
could produce an “entourage effect” whereby they modulate cannabinoids to result in …

Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …

While neuronal loss has long been considered as the main contributor to age-related
cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction …

The dorsal striatum is a key node for many neurobiological processes such as motor activity,
cognitive functions, and affective processes. The proper functioning of striatal neurons relies …

At present, clinical interest in the plant-derived cannabinoid compound cannabidiol (CBD) is
rising exponentially, since it displays multiple therapeutic properties. In addition, CBD can …

The endocannabinoid system (ECS) is abundantly expressed in the brain. This system
regulates a plethora of physiological functions and is composed of cannabinoid receptors …

The medial prefrontal cortex (mPFC) is involved in cognitive functions such as working
memory. Astrocytic cannabinoid type 1 receptor (CB1R) induces cytosolic calcium (Ca2+) …

Cannabinoid-mediated memory impairment is a concern in cannabinoid-based therapies.
Caffeine exacerbates cannabinoid CB 1 receptor (CB 1 R)-induced memory deficits through …