Glucose and insulin metabolism in patients with diabetes are profoundly altered by
advanced chronic kidney disease (CKD). Risk of hypoglycemia is increased by failure of …

Background Type 2 diabetes mellitus (DM) globally affects 18–20% of adults over the age of
65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous …

Renal ammonia metabolism and transport mediates a central role in acid-base homeostasis.
In contrast to most renal solutes, the majority of renal ammonia excretion derives from …

Advanced glycation end products (AGEs) are a heterogeneous group of molecules that
accumulate in plasma and tissues with advancing age, diabetes, and renal failure. There is …

According to current textbook wisdom the liver is the exclusive site of glucose production in
humans in the postabsorptive state. Although many animal and in vitro data have …

At variance with the current view that only liver and kidney are gluconeogenic organs,
because both are the only tissues to express glucose-6-phosphatase (Glc6Pase), we have …

Cell–cell and cell-matrix interactions control cell phenotypes and functions in vivo.
Maintaining these interactions in vitro is essential to both produce and retain cultured cell …

The management of hyperglycemia in patients with kidney failure is complex, and the goals
and methods regarding glycemic control in chronic kidney disease (CKD) are not clearly …

Glucose 6-phosphatase (EC 3.1. 3.9, Glc-6-Pase) 1 is a crucial enzyme in the control of
glucose homeostasis. It catalyzes the last biochemical reaction of gluconeogenesis and …

We studied in rats the expression of genes involved in gluconeogenesis from glutamine and
glycerol in the small intestine (SI) during fasting and diabetes. From Northern blot and …