[HTML][HTML] SIRT1 activation by natural phytochemicals: an overview

C Iside, M Scafuro, A Nebbioso, L Altucci - Frontiers in pharmacology, 2020 - frontiersin.org
Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …

Health benefits of resveratrol: Evidence from clinical studies

AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Focus on receptors for coronaviruses with special reference to angiotensin-converting enzyme 2 as a potential drug target-a perspective

T Magrone, M Magrone, E Jirillo - Endocrine, Metabolic & …, 2020 - ingentaconnect.com
Coronaviruses (CoVs) possess an enveloped, single, positive-stranded RNA genome that
encodes for four membrane proteins, namely spike (S), envelope (E), membrane (M) and …

[HTML][HTML] Diet, lifestyle and cardiovascular diseases: linking pathophysiology to cardioprotective effects of natural bioactive compounds

J Sharifi-Rad, CF Rodrigues, F Sharopov… - International journal of …, 2020 - mdpi.com
Heart and blood vessels disorders comprise one of the main causes of death worldwide.
Pharmacologically active natural compounds have been used as a complementary therapy …

[HTML][HTML] Resveratrol and vascular function

H Li, N Xia, S Hasselwander, A Daiber - International journal of molecular …, 2019 - mdpi.com
Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating
the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and …

Antioxidant effects of resveratrol in the cardiovascular system

N Xia, A Daiber, U Förstermann… - British journal of …, 2017 - Wiley Online Library
The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …

[HTML][HTML] Biological activities of stilbenoids

BC Akinwumi, KAM Bordun, HD Anderson - International journal of …, 2018 - mdpi.com
Stilbenoids are a group of naturally occurring phenolic compounds found in various plant
species. They share a common backbone structure known as stilbene, but differ in the …

[HTML][HTML] Progress to improve oral bioavailability and beneficial effects of resveratrol

A Chimento, F De Amicis, R Sirianni… - International journal of …, 2019 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present
in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro …

[HTML][HTML] Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signaling in cardiovascular diseases: a mini review

KW Choy, D Murugan, XF Leong, R Abas… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and
heart failure are the leading causes of morbidity and mortality worldwide. One of the major …

Effect of resveratrol and pterostilbene on aging and longevity

YR Li, S Li, CC Lin - Biofactors, 2018 - Wiley Online Library
Over the past years, several studies have found that foods rich in polyphenols protect
against age‐related disease, such as atherosclerosis, cardiovascular disease, cancer …