BACKGROUND: Translational research suggests that D-cycloserine (DCS), a partial N-
methyl-D-aspartate (NMDA) receptor agonist, might facilitate fear extinction and exposure …

Since the finding by Johnson and Ascher (1987) demonstrating that glycine enhances
electrophysiological responses mediated by N-methyl-D-aspartate (NMDA) b

Background Traditional pharmacological approaches to treating psychiatric disorders focus
on correcting presumed biochemical abnormalities. However, some disorders, particularly …

Glutamate is the primary excitatory neurotransmitter in the mammalian brain. Glutamatergic
neurotransmission may be modulated at multiple levels, only a minority of which are …

Context Social anxiety disorder (SAD) is common and debilitating. Although exposure
therapy is one of the most effective forms of psychotherapy for this disorder, many patients …

Administration of benzodiazepines or serotonin reuptake inhibitors in combination with
behavior therapy for the treatment of many anxiety disorders has generally lead to only …

Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …

Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors and
agonist of the glycine-B coagnoist site of these receptors have been important tools for …

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium
permeability that play important roles in many aspects of the biology of higher organisms …

D-Cycloserine, known from tuberculosis therapy, has been widely introduced to
neuropsychiatric studies, since its central active mechanism as a partial NMDA-agonist has …