The BCl-2 family has long been identified for its role in apoptosis. Following the initial
discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous …

Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian
survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3 …

Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …

With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …

The incidence of diabetes has been increasing in recent decades which is affecting the
population of both, developed and developing countries. Diabetes is associated with micro …