Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

While some DNA base modifications such as 5-methylcytosine have been known and
studied for decades, recent discoveries of a number of other modified bases have stimulated …

Nucleosomes are the basic unit of chromatin that help the packaging of genetic material
while controlling access to the genetic information. The underlying DNA sequence, together …

Histones and many other proteins react with abundant endogenous DNA lesions,
apurinic/apyrimidinic (abasic, AP) sites and/or 3′-phospho-α, β-unsaturated aldehyde (3 …

Telomere maintenance is a hallmark of malignant cells and allows cancers to divide
indefinitely. In some cancers, this is achieved through the alternative lengthening of …

Radical cations (holes) produced in DNA by ionizing radiation and other oxidants yield DNA–
protein cross-links (DPCs). Detailed studies of DPC formation in chromatin via this process …

Methylation of cytosine at the 5-position is a common epigenetic modification in mammalian
DNA and plays an important role in regulating gene expression. Oxidized derivatives of 5 …

Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and
display some unusual genomic and epigenetic properties that provide valuable insight into …

Abstract Linear or branched 1, 3‐diketone‐linked thymidine 5′‐O‐mono‐and triphosphate
were synthesized through CuAAC click reaction of diketone‐alkynes with 5‐azidomethyl …

Covalent binding of DNA to proteins produces DNA− protein cross-links (DPCs). DPCs are
formed as intermediates of enzymatic processes, generated from the reactions of protein …