Allostery is a ubiquitous process for protein regulatory activity in which a binding event can
change a protein's function carried out at a distal site. Despite intensive theoretical and …

PDZ (postsynaptic density (PSD95), discs large (Dlg), and zonula occludens (ZO-1)-
dependent interactions are widely distributed within different cell types and regulate a …

PICK1 is a modular scaffold implicated in synaptic receptor trafficking. It features a PDZ
domain, a BAR domain, and an acidic C-terminal tail (ACT). Analysis by small-angle x-ray …

PDZ (PSD-95/Dlg/ZO-1) binding domains often serve as cellular traffic engineers, controlling
the localization and activity of a wide variety of binding partners. As a result, they play …

The PDZ family has drawn attention as possible drug targets because of the domains' wide
ranges of function and highly conserved binding pockets. The PICK1 PDZ domain has been …

Recently, we described the first small-molecule inhibitor,(E)-ethyl 2-cyano-3-(3, 4-
dichlorophenyl) acryloylcarbamate (1), of the PDZ domain of protein interacting with Cα …

Modulating protein–protein interactions constitutes a promising strategy both for the
investigation of biological mechanisms and for developing new therapeutic approaches …

PDZ domains are modular domains that conventionally bind to C terminal or internal motifs
of target proteins to control cellular functions through the regulation of protein complex …

Equilibrium fluctuation analysis of single binding events has been used to extract binding
kinetics of ligand interactions with cell-membrane bound receptors. Time-dependent total …

The removal of AMPA receptors from synapses is a major component of long-term
depression (LTD). How this occurs, however, is still only partially understood. To investigate …