Protein interacting with C kinase-1 (PICK1) regulates intra-cellular trafficking of GluA2-
containing AMPA receptors, a process known to play a critical role in cocaine-seeking …

β-Strand mediated protein–protein interactions (PPIs) represent underexploited targets for
chemical probe development despite representing a significant proportion of known and …

Abstract Background Prokineticin 2 (PK2) is a secreted protein and causes potent
hyperalgesia in vivo, and is therefore considered to be a new pronociceptive mediator …

Protein interacting with C kinase 1 (PICK1) is a scaffolding protein mainly implicated in
neurological diseases, however, the function of PICK1 in acute liver injury (ALI) remains …

The serotonin transporter (SERT) functions to transport serotonin (5-HT) from the
extracellular space into neurons to maintain homeostatic control of 5-HT. It is the molecular …

Prolactin (PRL) is a polypeptide hormone produced and released from the pituitary and
extrapituitary tissues. It regulates activity of nociceptors and causes hyperalgesia in pain …

Recognition of short linear motifs (SLiMs) or peptides by proteins is an important component
of many cellular processes. However, due to limited and degenerate binding motifs …

γ-aminobutyric acid type B (GABAB) receptors play a critical role in neuronal excitability and
modulation of synaptic neurotransmission in the central nervous system. They are G protein …

Aim To explore the inhibitory effect of FSC231, a PDZ domain inhibitor of protein interacting
with C kinase 1 (PICK1), on paclitaxel induced neuralgia and its possible pathways …

PDZ domains are protein-protein interaction modules that coordinate multiple signaling and
trafficking pathways in the cell and that include active therapeutic targets for diseases such …