Protein interacting with C kinase (PICK1) is well conserved throughout evolution and plays a
critical role in synaptic plasticity by regulating the trafficking and posttranslational …

Protein–protein interactions have become attractive targets for both experimental and
therapeutic interventions. The PSD-95/Dlg1/ZO-1 (PDZ) domain is found in a large family of …

Postsynaptic receptor trafficking plays an essential role in tuning neurotransmission and
signal plasticity and has emerged as a potential therapeutic target in neuropsychiatric …

Iron accumulation, which is controlled by transferrin receptor 1 (TfR1), modulates hypoxia-
inducible factor-1α (HIF-1α) activation and angiogenesis of hypoxic endothelial cells. The …

Best known for its interaction with the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic
acid receptor subunit GluA2 and for its influence on excitatory synapse activity, the protein …

The knowledge that excitatory synapses on aspiny hippocampal interneurons can develop
genuine forms of activity-dependent remodeling, independently from the surrounding …

Abstract Voltage‐gated Ca2+ (CaV) channels are crucial for neuronal excitability and
synaptic transmission upon depolarization. Their properties in vivo are modulated by their …

PDZ (PSD-95/Discs-large/ZO-1 homology) domains represent putative targets in several
diseases including cancer, stroke, addiction and neuropathic pain. Here we describe the …

The CFTR-associated ligand PDZ domain (CALP) binds to the cystic fibrosis transmembrane
conductance regulator (CFTR) and mediates lysosomal degradation of mature CFTR …

PDZ domains, which belong to protein–protein interaction networks, are critical for
regulating important biological processes such as scaffolding, trafficking, and signaling …