The parathyroid hormone 1 receptor (PTH1R) is activated by parathyroid hormone (PTH)
and parathyroid hormone related protein (PTHrP), hormones that mediate mineral ion …

Willed-movement (WM) training has been implicated in the promotion of motor function in
human stroke survivors and focal ischemic rats. However, the molecular basis of changes in …

The parkin‐associated endothelial‐like receptor (PAELR, GPR 37) is an orphan G protein‐
coupled receptor that interacts with and is degraded by parkin‐mediated ubiquitination …

Choanoflagellates are single-celled eukaryotes with complex signaling pathways. They are
considered the closest non-metazoan ancestors to mammals and other metazoans and form …

Abstract PDZ (PSD‐95, Dlg, ZO‐1) domains are ubiquitous interaction modules that are
involved in many cellular signal transduction pathways. Interference with PDZ‐mediated …

The calcineurin/nuclear factor of activated T cell (NFAT) signaling pathway plays a major
role in osteoclast differentiation; however, the proteins that react with the calcineurin-NFAT …

The human memory-associated protein KIBRA regulates synaptic plasticity and trafficking of
AMPA-type glutamate receptors, and is implicated in multiple neuropsychiatric and cognitive …

PICK1 (Protein interacting with C kinase-1) plays a key role in the regulation of intracellular
trafficking of AMPA GluA2 subunit that is linked with synaptic plasticity. PICK1 is a …

In this issue of the Biochemical Journal, Zhang et al. reveal a new strategy for modifying the
regulated function of CFTR (cystic fibrosis transmembrane conductance regulator) on the …

The TEM family of enzymes has had a crucial impact on the pharmaceutical industry due to
their important role in antibiotic resistance. Even with the latest technologies in structural …